Report states that an old malaria drug known as Chloroquine effectively inhibits coronavirus infection and spread.
In
a three-page paper published in Cell Research, scientists at the Wuhan
Institute of Virology’s State Key Laboratory of Virology wrote that both
Chloroquine and the antiviral Remdesivir were, individually, “highly
effective” at inhibiting replication of the novel coronavirus in cell
culture.
According
to the paper, an efficient approach to drug discovery is to test
whether the existing antiviral drugs are effective in treating related
viral infections.
Several
FAD-approved drugs were tested, including ribavirin, penciclovir,
nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum
antiviral drugs remdesivir and favipiravir against a clinical isolate of
2019-nCoV (coronavirus) in vitro.
Among
the tested drugs, two compounds – remdesivir and chloroquine -potently
blocked virus infection at low-micromolar concentration and showed high
SI, it was revealed.
Remdesivir
has been recently recognized as a promising antiviral drug against a
wide array of RNA viruses (including SARS/MERS-CoV) infection in
cultured cells, mice and nonhuman primate (NHP) models. It is currently
under clinical development for the treatment of Ebola virus infection.
Chloroquine,
a widely-used anti-malarial and autoimmune disease drug, has recently
been reported as a potential broad-spectrum antiviral drug. Chloroquine
is known to block virus infection by increasing endosomal pH required
for virus/cell fusion. Besides its antiviral activity, chloroquine has
an immune-modulating activity, which may synergistically enhance its
antiviral effect in vivo.
The scientists concluded by stating: “Our
findings reveal that remdesivir and chloroquine are highly effective in
the control of 2019-nCoV (coronavirus) infection in vitro. Since these
compounds have been used in human patients with a safety track record
and shown to be effective against various ailments, we suggest that they
should be assessed in human patients suffering from the novel
coronavirus disease.”
When
Nigerians heard about the effectiveness of chloroquine in treating
coronavirus, they took to Twitter to react to it and to reminisce on
their experiences using chloroquine while growing up.
See some tweets below.
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